Adult Onset Still’s disease (AOSD) is a systemic inflammatory disorder of unknown aetiology. Rarely, it may be complicated by Macrophage Activation Syndrome (MAS), a multisystem inflammatory syndrome caused by massive cytokine release from activated lymphocytes and macrophages. Macrophage activation syndrome associated with adult-onset Still's disease: a multicenter retrospective analysis MAS occurrence is the major cause of death in AOSD rucks.xyz by: 5.
Macrophage activation syndrome (MAS) has been reported up to 15% of AOSD patients and it is considered to be the most severe complication of the disease being characterised by high mortality rate. During AOSD, laboratory tests reflect the systemic inflammatory process showing high levels of erythrocyte sedimentation rate and C-reactive rucks.xyz by: Macrophage activation syndrome (MAS) is a potentially fatal complication of Adult-Onset Still’s disease (Still’s disease). Whereas an increasing body of evidence supports interleukin-1 (IL-1) blockade as a promising treatment for Still’s disease, whether it is therapeutic for MAS associated with Still’s disease remains rucks.xyz by: