We present a case of recurrent Henoch-Schonlein purpura (HSP) complicated by nephritis in an adult female initially categorized as IgA nephropathy (IgAN). We review the pathophysiologic basis of HSP nephritis as the variant of HSP accompanied by renal involvement and its pathogenetic commonality with IgA nephropathy. High sensitivity can be defined as acute physical, mental, and emotional responses to external (social, environmental) or internal (intra-personal) stimuli. A highly sensitive person may be an.
Henoch-Schonlein purpura (also known as IgA vasculitis) is a disorder that causes the small blood vessels in your skin, joints, intestines, and kidneys to become inflamed and bleed. The most striking feature of this form of vasculitis is a purplish rash, typically on the lower legs and buttocks. HSP is a heterogeneous disorder manifesting in adults with palpable purpura/skin vasculitis, hematuria and proteinuria, often with preserved renal function. The diagnosis can be easily missed: A high degree of suspicion and requesting immuno-fluorescence studies in suspected cases are mandatory to establishing the diagnosis.
HSP should be considered in the differential diagnosis of any adult patient who presents with purpura, arthralgias, and kidney disease manifested by proteinuria and active urinary sediment, with or without kidney failure. HSP often affects children, but can affect adult of all ages. It often follows an infection, which is frequently tonsillitis in younger patients, a throat or chest infection, or a bout of gastroenteritis. It affects both sexes equally. Half the children affected are under the age of five.
HSP is more common in children than adults, but has a tendency to be more severe when it occurs in adults. In a small minority of cases, HSP can cause severe kidney or bowel disease. Highly sensitive people are more aware of subtleties and details that could make decisions harder to make, Aron says. Even if there is no "right" or "wrong" decision -- for example, it's impossible to choose a "wrong" flavor of ice cream -- highly sensitive people will still tend to take longer to choose because they are weighing every possible outcome.